FORUM 2026

8^th SIRC Forum “New Roads in Cardiovascular Research”

Con il Supporto di

DATA FORUM:

25-26 Giugno 2026 

PROGRAM:

DAY 1 – Afternoon (25/06/2026)

13:30 – 14:00 Registration / Poster setup

14:00 – 14:30 Welcome and Introduction

• Prof. Marco Emilio ORLANDI (Rector of the University of Milano-Bicocca)
• Prof. Francesca GRANUCCI (Director of the Department of Biotechnology and Biosciences of the University of Milano-Bicocca)
• Prof. Vincenzo LIONETTI (SIRC President) 

14:30 – 15:30 SYMPOSIUM #1 – Novel experimental strategies and integrative approaches in cardiovascular research  
Chairs: Luca SALA (Auxologico Milano) – Laura SARTIANI (University of Florence)

14:30 – 14:45 Silvia BERRETTONI (University of Parma) – Silicon carbide nanowires preserve human atrial microtissue function and show a preliminary reduction of AF duration in an aged-rat atrial tachypacing model

14:45 – 15:00 Antonietta BUONAIUTO (University of Naples) – Mitochondrial Dysregulation in Fabry Disease and the Potential Impact of Beta-Hydroxybutyrate

15:00 – 15:15 Simone DE PRÀ (Italian Institute of Technology) – Non-invasive action potential recording from hiPSC-derived cardiomyocytes using Electrolyte Gated Organic Transistors

 15:15 – 15:30 Cecilia THAIRI (Humanitas Research Hospital) – Advanced 3D Cardiac Modelling of LMNA-related Cardiomyopathy

15:30 – 16:30 Coffee Break (“Galleria della scienza”) and Poster Session #1 
Chairs: Roberta DE ZIO (University of Bari) – Francesco MOCCIA (University of Molise)

16:30 – 17:15 PLENARY LECTURE #1
Introduced by Francesco LODOLA (University of Milano-Bicocca)

Prof. Dr. Peter KOHL (University of Freiburg) – The Non-Textbook Heart: Structure, Electrics, Mechanics

 17:15 – 18:15 SYMPOSIUM #2 – Molecular and cellular mechanisms in cardiovascular function and disease 
Chairs: Carmine ROCCA (University of Calabria) – Daniela SORRIENTO (University of Naples)

 17:15 – 17:30 Giada ALLEGRO (University of Florence) – A preliminary study of the impact of congenital cardiac arrhythmias on heart–brain axis overtime: insightful evidences using the zebrafish model and cardiomyocytes from hiPSCs

 17:30 – 17:45 Martina ARICI (University of Milano-Bicocca) – Unveiling pro-arrhythmic effects of PITX2 gain-of-function mutation associated with atrial fibrillation

 17:45 – 18:00 Sofia MILASI (Centro Cardiologico Monzino) – Understanding and targeting myocarditis in patients with desmosomal gene mutations

 18:00 – 18:15 Ivan SHERSTNEV (University of Torino) – PI3Kγ Mimetic Peptide as a Nanodomain-Targeted Positive Inotrope in Cardiomyocytes

 20:00 Social Dinner
Ristorante SottoSopra – Viale Piero e Alberto Pirelli 16, Milano

DAY 2 – (26/06/2026)

09:00 – 10:00 SYMPOSIUM #3 – Translational perspectives and emerging therapeutic directions in cardiovascular research

Chairs: Daniele MANCARDI (University of Torino) – Marcella ROCCHETTI (University of Milano-Bicocca)

 09:00 – 09:15 Marica DENTE (University of Florence) – Mutation-related efficacy of novel therapeutic approaches in hypertrophic cardiomyopathy

 09:15– 09:30 Teresa Maria FORMICA (University of Pavia) – Inhalable nanoparticles mediate cardiotropic delivery of allele specific siRNA in a mouse model of Catecholaminergic Polymorphic Ventricular Tachycardia

 09:30 – 09:45 Chiara FLORINDI (CNR – Pisa) – Light-driven termination of cardiac reentry: precise, non-genetic control of arrhythmogenic dynamics using the membrane-targeted photoswitch Ziapin2

09:45 – 10:00 Naomi ROMEO(University of Calabria) – Selenoprotein T attenuates age-related left and right ventricular susceptibility to ischemia/reperfusion injury via modulation of ferroptosis-mitochondrial axis

10:00 – 11:00 Coffee Break (“Galleria della scienza”) and Poster Session #2
Chairs: Astrid PARENTI (University of Florence) – Stefano ROSSI (University of Parma)

 11:00 – 11:45 PLENARY LECTURE #2
Introduced by Michele SAMAJA (Fondazione Martina Samaja)

Prof. Sandra LINDSTEDT (Lund University) – Restoration of Organs for Transplantation

11:45 – 12:15 Tito Mancardi Award

Chairs: Elide DELPONTE (Fondazione Tito Tocca Colore) – Vincenzo LIONETTI (Scuola Superiore Sant’Anna, Pisa)

 12:15 – 12:30 Oral and poster presentation Awards

 12:30 – 13:30 Meeting SIRC / Closing Remarks

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SCIENTIFIC COMMITTEE

Vincenzo LIONETTI – President
Tommaso ANGELONE
Elena GUZZOLINO
Francesco LODOLA
Rosalinda MADONNA
Daniele MANCARDI
Pasquale PAGLIARO
Astrid PARENTI
Claudia PENNA
Carmine ROCCA
Marcella ROCCHETTI
Stefano ROSSI
Michele SAMAJA
Daniela SORRIENTO

LOCAL ORGANIZING COMMITTEE

Francesco LODOLA
Marcella ROCCHETTI

SECRETARY OF THE FORUM

Elena GUZZOLINO

REGISTRAZIONE AL FORUM:

Di seguito sono presenti le modalità di registrazione al forum
Early registration: entro il 08/05/2026.
Late: bonifico o in sede (contanti)

Le quote di registrazione previste sono:

Il pagamento può essere effettuato mediante bonifico bancario su:
Intestazione: SOCIETA’ ITALIANA RICERCHE CARDIOVASCOLARI VIA IRNERIO 48 – 40126 BOLOGNA (BO)
Iban: IT79Z0306909606100000174834

La ricevuta di pagamento deve essere inviata a segreteriasirc@sirc-cardio.it.

E’ possibile utilizzare lo stesso IBAN per regolarizzare le quote di iscrizione alla SIRC; anche in questo caso la ricevuta di pagamento dovrà essere inviata a segreteriasirc@sirc-cardio.it.

ASTRACT SUBMISSION

Sarà possibile sottomettere i propri Abstract a partire dal 16 Marzo 2026 fino alle ore 12:00 dell’8 Maggio 2026.

Sottometti Abstract »

DIMENSIONI POSTER

I poster devono avere un orientamento verticale e rispettare le misure di 70×100 cm (lunghezza x altezza).

Poster session 1 (June 25, 2026)

1. Unveiling doxorubicin-induced metabolic reprogramming and phenotypic remodelling in cardiac fibroblasts: a novel perspective on anthracycline cardiotoxicity. Niro, G. Guerra, A. Ghigo. University of Turin, Italy.
2. Optically-driven maturation of human cardiomyocytes via a far-red sensitive organic semiconductor. Ronchi, C. Galli, G. Tullii, N. Salvarani, S. Puccio, M. Malferrari, C. Marzuoli, M. Erreni, F. Falciani, J. Kourourdis, A. Gagliardi, S. Rapino, M. R. Antognazza and E. Di Pasquale. Humanitas Cardio Center, IRCCS, Milan, Italy.
3. Development of a dynamic in vitro endothelial model through MIVO technology. Shelton Agar, D. Mancardi, E. Arrigo, M. Radin, I. Cecchi, A. Barinotti, S. Sciascia. University of Turin, Italy.
4. PKP2-mRNA-based therapy for the treatment of Arrhythmogenic Cardiomyopathy (ACM). Vigorito, M. Lippi, S. Zacchigna, D. Barisani, Y. Santin, S. Maione, E. Sommariva. Centro Cardiologico Monzino IRCCS, Milano, Italy.
5. Recapitulating HF phenotype in vitro exploiting hiPSCs-derived cardiomyocytes. Zaccaria, M. Arici, G. Ducci, E. Lazzarini, A. Metallo, G. Zeppellini, E. Sacco, C. Altomare, L. Barile, M. Rocchetti. University of Milano-Bicocca, Italy.
6. Tyrosol and hydroxytyrosol protect against distinct models of cardiac injury. Femminò, R. Ciullo, G. Magalì, S. Siklaoui, F. Trotta, P. Pagliaro, C. Penna. University of Turin, Italy.
7. Integrated clinical, functional and structural characterization of a novel KCNQ1 genetic variant associated with Long-QT Syndrome Type 1. Balducci, L. Carraresi, G. Allegro, G. Napoli, V. Spinelli, M. L. Boccitto, C. Sala, I. Olivotto, F. Girolami, G. Calabri, A. Gozzini, L. Sacconi, E. Cerbai, E. Guzzolino, L. Sartiani. University of Florence, Italy.
8. Sex-dependent effects of systemic inflammation on aortic valve remodeling: focus on interferon β. Bertolini, V. Valerio, P. Gripari, V. Mantegazza, V. Rusconi, I. Massaiu, M. Zanobini, M. Agrifoglio, V. A. Myasoedova, P. Poggio. Centro Cardiologico Monzino IRCCS, Milan, Italy.
9. SARS-COV2: impact and therapeutic implications of Envelope viroporin in human cardiovascular alterations. L. Boccitto, C. Sala, A. Ninu, V. Balducci, G. Allegro, G. Nesi, M. Focardi, A. Arcangeli, E. Guzzolino, V. Spinelli, L. Sartiani, E. Cerbai. University of Florence, Italy.
10. Novel insights into the role of Piezo1 channel in the human cerebrovascular endothelial cell line, hCMEC/D3. Brunetti, G. Chinigò, M. Cavallo, F. Moccia, G. Scarpellino. University of Pavia, Italy.
11. Interleukin-6: a key modulator of cardiac nodal cells activity. Canzolino, D. Molla, A. Egidi, R. Han, P. Benzoni, M. Baruscotti, A. Bucchi. University of Milan, Italy.
12. Physical exercise improves skeletal muscle endurance in a murine model of fabry disease. A. Cerasuolo, J. Gambardella, A. Fiordelisi, R. Avvisato, A. Buonaiuto, G. Santulli, D. Sorriento, G. Iaccarino. University of Naples, Italy.
13. Recirculation fraction as a functional readout of SERCA2a activity in mouse ventricular cardiomyocytes. Maniezzi, F. Misitano, E. Distefano, F. Lodola, A. Zaza. University of Milano Bicocca, Italy.
14. NLRP3 inhibition by INF195 prevents oxidative stress and barrier dysfunction in human cardiac microvascular endothelial cells. Femminò, G. Querio, S. Siklaoui, S. Antoniotti, A. Ammirati, M. Bertinaria, P. Pagliaro, M.P. Gallo, C. Penna. University of Turin, Italy.
15. Implications of altered PKA/phosphatase equilibrium in the nucleus. M. A. Forlini, F. Conca, D. Steffan, G. Favaro, D. K. Bayburtlu, A. Tavoni, M. Vismara, N. C. Surdo, G. Di Benedetto, C. Lucca, M. Sandri and K. Lefkimmiatis. University of Pavia, Italy.
16. Investigating Arrhythmogenic Risk in Long QT Syndrome Type 2. Makkieh, A. Di Mise, G. Rurale, L. Crotti, P. J. Schwartz, L. Sala. Istituto Auxologico Italiano, IRCCS, Milan, Italy.
    

Poster session 2 (June 26, 2026) 

17. Cellular consequences of non-ablative radiotherapy, a novel approach to ventricular tachycardias. Maniezzi, S. Busti, A.S. Maione, E. Sommariva, C. Florindi, F. Misitano, I. Anzaldi, F.P. Cammarata, G.I. Forte, R. Catalano, G.M. De Ferrari, F. Lodola and A. Zaza. University of Milano-Bicocca, Milan, Italy.
18. Chemotherapeutics agents Bortezomib and Carfilzomib impact on the electrophysiology of human-induced pluripotent stem cells-derived cardiomyocytes. Melgari, S. Calamaio, A. Frosio, R. Prevostini, A. Malacrida, G. Cavaletti, G. Nicolini, L. Anastasia, C. Pappone, I. Rivolta. IRCCS Policlinico San Donato, San Donato Milanese, Milano, Italy.
19. HCN1 plays a fundamental role in cardiac pacemaker synchronization. Orabona, C. Piantoni, K. Hennis, L. Pham, M. Schänzler, N. Auerbach, M. Hörzing, Y. Wu, R. Rötzer, A. Kohlrautz, C. Feldmann, M. Gonzalez Pisfil, D. Kruck, J. Rilling, B. Averbeck, V. O. Nikolaev, M. Biel, C. Leibold, S. Fenske, C. Wahl-Schott. Ludwig-Maximilians-Universität München, Planegg-Martinsried, Germany.
20. Voltage imaging of sinoatrial node pacemaking during direct right vagal stimulation. Piantoni, V. Brox, M. Nemati, K. Hennis, M. Biel, I. Efimov, S. Fenske, C. Wahl-Schott. Ludwig-Maximilians-Universität München, Planegg-Martinsried, Germany.
21. Differential regulation of adipogenesis by SGLT2 inhibitors: comparative effects of Empagliflozin and Dapagliflozin. Rusconi, I. Massaiu, V. Valerio, F. Bertolini, C. Molinari, V. A. Myasoedova, S. Genovese, P. Poggio. University of Naples, Italy.
22. A novel short isoform of Melusin reveals distinct subcellular localization and function in human cardiomyocytes. Savorè, M. Sorge, M. Brancaccio, A. Bertero. University of Turin, Italy.
23. Human cardiac organoids unveil an uncharacterized role of Melusin in left ventricle organogenesis. Becca, G. Savorè, N. Ruggiero, E. M. Hahn, D. Acquarone, F. Pasqualini, M. Brancaccio, A. Bertero, M. Sorge. University of Turin, Italy.
24. Molecular identification of a novel If-selective bradycardic agent isolated from TMYX: a cardioactive drug used in the Traditional Chinese Medicine. Han, A. Egidi, S. Canzolino, H. Zhu, P. Benzoni, S. Liu, Y. Wang, Y. Wang, L. Miao, Z. Junhua, A. Bucchi, M. Baruscotti. University of Milan, Italy.
25. Cilengitide treatment decreases the fibrosis in adventitial fibroblasts cultured in a patient-derived advanced 3D in vitro model of thoracic aortic aneurysm. Brusati, S. Rega, C. Russo, F. Riva, S. Zacchigna, M. Soncini, G. L. Perrucci. Centro Cardiologico Monzino IRCCS, Milan, Italy.
26. Synergistic inotropic effects of Istaroxime and Levosimendan in human failing myocardium. Giacomelli, M. Dente, G. Panichella, M. Scardigli, M. Langione, G. Malfatto, C. Poggesi, A. Zaza, F. Lodola, M. Pioner, C. Ferrantini. University of Florence, Italy.
27. Long-term treatment of HCM hiPSC-derived cardiomyocytes with myosin inhibitors reduces contractile force and induces reversible sarcomeric remodeling. Langione, L. Giammarino, R. Semeraro, B. Scellini, S. Steczina, V. Spinelli, E. Martelli, I. Della Corte, C. Olianti, A. Magi, L. Sacconi, E. Cerbai, M. Regnier, I. Olivotto, C. Tesi, C. Poggesi, R. Coppini, C. Ferrantini, J. M. Pioner. University of Florence, Italy.
28. Empagliflozin rescues functional alterations in early-stage Arrhythmogenic Cardiomyopathy. Lanzi, C. Maniezzi, C. Marrix, L. Iengo, S. Milasi, F. Lodola, A. Zaza, E. Sommariva, A. S. Maione. Centro Cardiologico Monzino IRCCS, Milan, Italy.
29. From metabolic insight to therapy: the genesis of SEARCH randomized clinical trial with statins in arrhythmogenic cardiomyopathy. Sommariva, M. Lippi, F. Bruttini, F. Cannata, R. Maragna, A. Baggiano, M. Schiavone, G. Pompilio, G. Pontone, M. Muratori, A. Turco, G. Limongelli, R. Lombardi, M. Casella, C. Tondo. Centro Cardiologico Monzino IRCCS, Milan, Italy.
30. Intrinsic sex-dependent remodelling pathways in CAVS determine divergent therapeutic effects of GLP-1 signalling. Massaiu, F. Bertolini, V. Valerio, V. Rusconi, V. A. Myasoedova, C. Molinari, S. Genovese, M. Franchi and P. Poggio. Centro Cardiologico Monzino IRCCS, Milan, Italy.
31. Spatial characterization of cardiac lipid remodelling after epicardial patch implantation in a rat myocardial infarction model. Doronzo, M.G. Perrelli, C. Cristallini, S. Burchielli, C. Kusmic, N. Barbani, C. Trouki, D. Rossino, N. Al-Mawed, R. Vanni, C. Giachino, R. Rastaldo. University of Turin, Italy.
32. Sirtuin 1 modulation unlocks the therapeutic potential of sodium-glucose co-transporter 2 inhibitors (SGLT2i) in calcific aortic valve stenosis. Valerio, I. Massaiu, M. Franchi, A. Rimbert, Z. Begué-Racapé, M. Chiesa, V. A. Myasoedova, V. Rusconi, F. Bertolini, D. De Giorgi, A. Bonomi, S. Pirola, M. Zanobini, P. Di Pietro, A. Carrizzo, M. Ciccarelli, R. Capoulade, S. Genovese, and P. Poggio. Centro Cardiologico Monzino IRCCS, Milan, Italy.

Premio di Studio SIRC “Tito Mancardi”

PER LA FORMAZIONE NELL’AMBITO DELLE MALATTIE CARDIOVASCOLARI E POLMONARI CONGENITE

La Società Italiana di Ricerche Cardiovascolari (SIRC), in attuazione delle disposizioni della Famiglia Mancardi, indice per l’anno 2026 il concorso per il Premio di Studio SIRC “Tito Mancardi”.

Sarà possibile sottomettere la propria candidatura fino alle ore 24:00 del 15 Maggio 2026.

Invia candidatura »    Scarica il bando »

CONFERENCE VENUE:

Aula Luisella Sironi (U4-8) 
University of Milano-Bicocca
piazza della scienza, 2
2026 Milano

Conference room and registration location:

Aula L. Sironi, U4 building, (-1 floor)

Clicca QUI per calcola il percorso per raggiungere il forum.

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